An imbalance of the oxidoreductive system has been observed with an ‘elevation of oxidative stress markers (superoxide dismutase, malondialdehyde, ROS) and antioxidant activity. Therefore, the hypothesis has been advanced that the melanocyte, as a result of oxidative stress-induced cellular damage, which causes cell death by melanocyte apoptosis, may unmask or release proteins that subsequently serve as antigens and activate the cell-mediated immune response against other melanocytes. In such observations lies the rationale for the use of topical and/or systemic antioxidants in the treatment of vitiligo, the use of which several open trials support.

Among the various substances with antioxidant power, PIPER NIGRUM, a plant belonging to the Piperaceae family and cultivated mainly in tropical regions (Indonesia, Brazil and India), is particularly interesting in vitiligo.

This particular species owes its antioxidant properties, along with its antihistamine, antimicrobial properties, to its main alkaloid, piperine. In addition, both in vitro and in vivo studies show that P. nigrum also has melanocyte proliferation-stimulating effects.

The repigmentation generally observed following the topical use of P. nigrum preparations follows a perifollicular pattern in the early stages, this finding is consistent with the scientific literature, which asserts precisely that repigmentation is possible in areas where there are pigmented hairs, an element suggestive of the presence of a melanin reservoir.

Another molecule of wide interest for its antioxidant power is the resveratrol, a component extracted from the roots of the plant Veratrum grandiflorum. It is a natural polyphenol produced by the plant as a result of UV damage or as a defense mechanism against pathogenic microorganisms. […]”