There is scientific evidence in the literature indicating that dry extracts of plants in the genera Hamamelidae, Pinus, and Vitis are rich in proanthocyanidins; in addition, there is evidence regarding the attested anti-inflammatory capacity of these active ingredients.

Dietary supplementation by proanthocyanidins can, therefore, help reduce inflammation and infection causing the typical manifestations of acne vulgaris. In addition, it can be an excellent support for antibiotic therapy, as proanthocyanidins are known to reduce bacterial antibiotic resistance in two ways:

• Preventing the formation of biofilms that bacteria use to adhere to substrates and protect themselves
• Inhibiting bacterial DNA transcription, thus the synthesis of enzymes responsible for antibiotic resistance.[4,5]

By virtue of the properties described above, Wikenfarma has formulated Dedalox: the first nutraceutical with proanthocyanidins developed for that patient with mild acne in whom it is premature to embark on a pharmacological course. Unlike other products that contain only generic trace elements, Dedalox exploits a precise scientific rationale to reduce inflammation and counteract skin microinfection.

In light of the above, to support antibiotic therapy in mild acne cases especially in the late spring and summer period (many antibiotics are known to be photosensitizing[6]) Wikenfarma has devised and recommends the following treatment protocol:

• Dedalox 2 cpr daily (morning and evening) combined with Kenflor 1 cp per day on an empty stomach during therapeutic vacations from antibiotics to limit photosensitization, fight acne, and restore physiological balance of gut microbiota
• Dedalox 1 cpr daily ( Morning) combined with Kenflor 1cp daily on an empty stomach during antibiotic treatment to maximize efficiency and maintain the physiological balance of the intestinal microbiota.