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THE FUNDAMENTAL FUNCTION OF NUCLEIC ACIDS IN AESTHETIC MEDICINE TREATMENTS
How hydrolyzed DNA and RNA can make a difference in an anti-aging formulation!
Index
Aesthetic medicine is that branch of medicine that focuses on the prevention and treatment of blemishes and aging, both cutaneous and systemic. Aesthetic medicine places its ultimate goal in achieving a state of health understood as psychophysical well-being, rather than as merely the absence of disease.
By virtue of this, ever since the birth of this discipline, more and more rigorous studies have been devoted to evaluating the mechanisms of aging and identifying active ingredients that can combat them.
Aesthetic medicine and skin aging
Female skin aging, especially, has been a primary topic of investigation for this new discipline, which, in recent years, has expanded its reach also to male skin aging.
This is a complex topic and is often caused by intrinsic factors, arising from the expression of our genetic makeup, and extrinsic factors, that is, caused by external agents and environmental factors.
The factors intrinsic cause reduced proliferative capacity, cellular senescence e reduced production of skin structural proteins over the years, consequently causing a change in skin aesthetics.[1]
Aging extrinsic, mainly due to UV exposure (photoaging), on the other hand, causes changes in cellular metabolism, which are mainly due to mutations induced by radiation exposure and a loss of dermal matrix cohesion.[2]
With advancing age, moreover, the junction epidermis/dermaflattens, with reduction of the dermal papillae, which makes the skin more fragile and vulnerable to forces applied along the parallel to the aforementioned junction. This is because the fibrous component that helps hold the junction firm undergoes significant structural changes with aging in general, and due to photoaging especially. As a consequence of UV exposure, situations of “elastosis”, i.e., increased production of elastin stimulated by solar radiation, which, however, does not conform to and fulfill its role of maintaining elastic tone, and is often associated with degeneration of collagen as well.[3]
The role of DNA and RNA hydrolysates
Among the various active ingredients identified for the purpose of improving skin appearance and combating such known issues of aging, DNA and RNA hydrolysates play a special role.
Such chemical species are able to play a dual role:first , the longer RNA fractions, consisting of between 18 and 24 nucleosides, if they can penetrate the epidermis and enter dermal cells are able to inhibit the expression of particular genes responsible for intrinsic aging, depending of course on the type of nucleosides present in the RNA fraction in question. Then they bind to and prevent the mRNA coding for the protein bound to the gene of interest from being read. [4]
For example, they are able to inhibit hyaluronidase, and ensure a higher concentration of hyaluronic acid in the skin, which has an important structural and moisturizing function. Deficiencies in hyaluronic acid, in fact, contribute to the loss of elastic skin tone and the formation of wrinkles.[5]
Second , such hydrolysates are molecules that can bind multiple water molecules, thus acting as moisturizing agents[6]. In addition, they also perform, to a lesser but no less important extent, the function of protect other biological molecules from damage by UV radiation and oxidation by oxygen radicals, oxidizing instead of DNA or other endogenous molecules.
The “Hyalufiller Cosmetic Drone”
By virtue of this, Wikenfarma research has included this important cosmetic ingredient in the anti-aging formulation Fillface Crema. In Fillface Cream, DNA and RNA hydrolysates play a synergistic action with the cosmetic drone Hyalufiller, since the latter stimulates fibroblasts to increase elastin production, thus counteracting age-related loss of elastic skin tone, while the short RNA fractions are able to inhibit the activation of enzymes that degrade hyaluronic acid and elastin, improving skin hydration and prolonging the improvement of skin tone over time.
Its uniqueness lies in the fact that it is able to reach and act on the deepest layers of the skin precisely because of the action of the cosmetic drone, as opposed to many other creams with an anti-aging effect that merely exert their effect at the surface level; for this reason, Fill Face Crema has physiologically become the most complete and effective for women who want to look forever young and have elastic and voluminous skin, as well as the most prescribed by aesthetic medicine specialists.
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