In the pathogenesis of almost all trichological disorders, there is a lowest common pathogenetic denominator, which isinflammation. We find this type of mechanism not only in androgenetic alopecia but also in Alopecia Areata and Telogen Effluvium. So it is basic in the economy of the treatment prescribed to the patient, to act by counteracting the inflammatory phenomena.

From a clinical point of view, scalp inflammation is manifested by symptoms such as scalp pain (trichodynia), burning, and itching. At trichoscopy, yellowish areas surrounding the hair follicles, called Yellow Dots, are identified and are the dermatoscopic counterpart of inflammation. Trichological pathologies and inflammation thus have a very profound correlation.

Treating an androgenetic alopecia requires both blocking the effects of dihydrotestosterone on the hair follicle and modulating inflammation and blocking it. The latter tends to create fibrosis phenomena which slowly superficialize the follicle, reducing follicular depth and Anagen phase. In worst-case scenarios, atrophy of the follicle can occur.

Both drug therapies, mainly low-potency corticosteroids in lotion form, and specific, targeted nutraceuticals systemically can be used to treat this inflammation.

Therefore, it is possible to intervene with anti-inflammatory agents that are not pharmacological, but natural, that is, from phytoextracts. These exert their action in a targeted manner: one active ingredient that can be used is EPILOBIO, which represents a novelty among phytoextracts in that it is a natural anti-inflammatory not yet used in trichology.

It is a natural anti-inflammatory that also has sedative, decongestant and soothing properties. It owes its characteristics to components called. ellagitannini. Epilobium reduces the release of mediators of acute inflammation, including LOX and COX, reduces the release of TNF-alpha, and exerts sebum-regulatory action as a 5-alpha-reductase inhibitor. Epilobium finds its maximum therapeutic expression when used in combination with classical therapy, for example with activators of mitotic activity such as Minoxidil or 5-alpha-reductase inhibitors such as Serenoa Repens in soft gel (92% oil) or Finasteride, associated with antioxidants. The optimal therapeutic approach is to manage the hormonal mechanisms of androgenetic alopecia on the one hand and to manage the inflammation.