{"id":23843,"date":"2026-02-23T16:08:32","date_gmt":"2026-02-23T15:08:32","guid":{"rendered":"https:\/\/wikenfarma.com\/multicenter-randomized-clinical-trial-of-a-nutraceutical-and-a-lotion-in-male-patients-with-androgenetic-alopecia\/"},"modified":"2026-04-30T15:25:13","modified_gmt":"2026-04-30T13:25:13","slug":"multicenter-randomized-clinical-trial-of-a-nutraceutical-and-a-lotion-in-male-patients-with-androgenetic-alopecia","status":"publish","type":"post","link":"https:\/\/wikenfarma.com\/en\/multicenter-randomized-clinical-trial-of-a-nutraceutical-and-a-lotion-in-male-patients-with-androgenetic-alopecia\/","title":{"rendered":"Multicenter randomized clinical trial of a nutraceutical and a lotion in male patients with androgenetic alopecia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"23843\" class=\"elementor elementor-23843 elementor-23671\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0536be3 e-flex e-con-boxed e-con e-parent\" data-id=\"0536be3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a4d8f9 e-con-full e-flex e-con e-child\" data-id=\"3a4d8f9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1642ce4 elementor-widget elementor-widget-heading\" data-id=\"1642ce4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Tricoblog<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9eca041 elementor-widget elementor-widget-heading\" data-id=\"9eca041\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Multicenter randomized clinical trial of a nutraceutical and a lotion in male patients with androgenetic alopecia\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ace55d elementor-widget elementor-widget-heading\" data-id=\"9ace55d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Paolo Gigli, Antonella Parlangeli, Cristian Giani, Gino Favero, Francesco Rinaldi, Maria Grazia Cusmai, Mauro Mazzeo, Elda De Leo, Lucia Villa, Donata Franchini, Antonia Liotino, Emanuela Barberio and Andrea Marliani.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968878d elementor-align-left elementor-widget elementor-widget-post-info\" data-id=\"968878d\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-24195a2 elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/author\/wikenfarma\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-user-circle\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\twikenfarma\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-e32289b elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/2026\/02\/23\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>February 23, 2026<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff8f5f9 elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"ff8f5f9\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;,&quot;h3&quot;,&quot;h4&quot;,&quot;h6&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;marker_view&quot;:&quot;numbers&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t<h4 class=\"elementor-toc__header-title\">\n\t\t\t\tIndex\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__ff8f5f9\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__ff8f5f9\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t<div id=\"elementor-toc__ff8f5f9\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b697456 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"b697456\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_tablet&quot;:&quot;zoomIn&quot;,&quot;_animation_mobile&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/restax-effluvium-30cpr\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-1024x683.jpg\" class=\"elementor-animation-shrink attachment-large size-large wp-image-15393\" alt=\"restax pre effluvium telogen effluvium spermidina\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-1024x683.jpg 1024w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-300x200.jpg 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-768x512.jpg 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-1536x1024.jpg 1536w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-2048x1365.jpg 2048w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/02\/adult-male-having-balding-problems-600x400.jpg 600w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7b907e elementor-widget elementor-widget-heading\" data-id=\"c7b907e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Introduction\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49d0ec6 elementor-widget elementor-widget-text-editor\" data-id=\"49d0ec6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-path-to-node=\"6\"><span data-path-to-node=\"6,2\"><span class=\"citation-310\">Androgenetic alopecia is a common problem in men, occurring on average between the ages of 35 and 45 years<\/span><\/span><span data-path-to-node=\"6,4\">.  <\/span><span data-path-to-node=\"6,6\"><span class=\"citation-309\">This disease has a genetic origin and is caused by the activity of dihydrotestosterone (DHT), which binds to androgen receptors at the follicular level and induces their progressive weakening, until the follicle atrophies, resulting in miniaturization and hair loss<\/span><\/span><span data-path-to-node=\"6,8\">.  <\/span><span data-path-to-node=\"6,10\"><span class=\"citation-308\">This type of alopecia is expressed by the typical Ludwig&#8217;s pattern, which begins at the top of the head and then extends toward the forehead joining with the receding hairline area<\/span><\/span><span data-path-to-node=\"6,12\">.  <\/span><span data-path-to-node=\"6,14\"><span class=\"citation-307\">Such retreat is due to the physiological action of testosterone, and conjunction with apical (vertex) hair loss often results in a situation of &#8220;crown&#8221; baldness, in which hair present in the parietal position and on the nape of the neck is spared from the onset of the problem because it is less sensitive to androgen hormones<\/span><\/span><span data-path-to-node=\"6,16\">.<\/span><\/p><p id=\"p-rc_eec4d48c11f18905-104\" data-path-to-node=\"7\"><span data-path-to-node=\"7,1\"><span class=\"citation-306\">For the treatment of Male Androgenetic Alopecia Androgenetica, a multifactorial approach is necessary: first, it is necessary to counteract the action exerted by DHT at the follicular level, so as to prevent follicle fibrosis and its atrophy; second, it is necessary to act by going to reduce the inflammatory component always present in this pathology<\/span><\/span><span data-path-to-node=\"7,3\">.  <\/span><span data-path-to-node=\"7,5\"><span class=\"citation-305\">This can be achieved either with low-dose pharmaceutical actives for topical use, usually containing cortisone or other corticosteroids, or with the use of specific, targeted nutraceuticals taken systemically<\/span><\/span><span data-path-to-node=\"7,7\">.  <\/span><span data-path-to-node=\"7,9\"><span class=\"citation-304\">In addition to these products taken by os, topical lotions containing anti-inflammatory agents of natural origin can be used<\/span><\/span><span data-path-to-node=\"7,11\">.  <\/span><span data-path-to-node=\"7,13\"><span class=\"citation-303\">The joint action of a nutraceutical and a lotion will be evaluated in this study in order to assess their effects in patients with AGA<\/span><\/span><span data-path-to-node=\"7,15\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6983375 elementor-widget elementor-widget-heading\" data-id=\"6983375\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">2. Study Target<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8ef5b7 elementor-widget elementor-widget-text-editor\" data-id=\"d8ef5b7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-path-to-node=\"8,2\"><span class=\"citation-302\">To evaluate the efficacy of a nutraceutical (Restax\u00ae Flogo 30cps) administered for a period of 3 months, (Restax\u00ae 30softgel+30cps) administered for an additional 3 months, and a hair lotion (Trivis AGA Men&#8217;s Lotion 100mL) administered for a period of 6 months in the treatment of patients presenting with symptoms of mild to moderate male androgenetic alopecia<\/span><\/span><span data-path-to-node=\"8,4\">.  <\/span><span data-path-to-node=\"8,6\"><span class=\"citation-301\">Assessing the reduction of hair loss, their possible increase in density and diameter, the evaluation will be done by means of a form filled out by the doctor at time 0 and after 6 months of treatment<\/span><\/span><span data-path-to-node=\"8,8\">.  <\/span><span data-path-to-node=\"8,10\"><span class=\"citation-300\">In addition, as a secondary end-point, the study aims to assess the tolerability of these products for use in chronic therapies<\/span><\/span><span data-path-to-node=\"8,12\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b80d385 elementor-widget elementor-widget-heading\" data-id=\"b80d385\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">3. Materials anf Method\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa7317c elementor-widget elementor-widget-text-editor\" data-id=\"fa7317c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-path-to-node=\"9\"><span data-path-to-node=\"9,2\"><span class=\"citation-299\">Each patient was asked during the first 3 months to take 1 capsule of Restax Flogo supplement daily, during dinner, and to apply the lotion every other day for a minimum of 3 times per week, applying 15 sprays to the affected areas, to damp or dry hair not necessarily washed before each application<\/span><\/span><span data-path-to-node=\"9,4\">. <\/span><span data-path-to-node=\"9,6\"><span class=\"citation-298\">For the next 3 months until study completion, the Restax Flogo supplement was replaced with Restax 30+30, of which the patient would take one capsule and one soft gel daily during dinner<\/span><\/span><span data-path-to-node=\"9,8\">.<\/span><\/p><p id=\"p-rc_eec4d48c11f18905-107\" data-path-to-node=\"10\"><span data-path-to-node=\"10,1\"><span class=\"citation-297\">The researcher after examination and history of the patient then filled out the questionnaire at T0 and T6, assessing clinical symptoms such as pull test result, presence of trichodynia, itching, and yellow dots around the follicles, using a scale of 0 to 5 where 0 indicated the absence of the symptom (and for the pull test 0 indicated negative result) and 5 indicated a very strong presence of the symptom (or a loss of a lot of hair during the pull test)<\/span><\/span><span data-path-to-node=\"10,3\">.  <\/span><span data-path-to-node=\"10,5\"><span class=\"citation-296\">The researcher then made dermatoscopic observations of the patient&#8217;s scalp, rating the patient&#8217;s overall status on a scale of 0 to 5, with 5 indicating very good satisfaction with the patient&#8217;s trichological status (regarding hair density per unit area and hair diameter) and 0 poor satisfaction<\/span><\/span><span data-path-to-node=\"10,7\">.  <\/span><span data-path-to-node=\"10,9\"><span class=\"citation-295\">The researcher then rated the patient&#8217;s situation against the Norwood-Hamilton scale of baldness, which has reference values from 1 to 7, with 1 indicating a normal situation and 7 indicating advanced androgenetic alopecia<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3208e81 elementor-widget elementor-widget-text-editor\" data-id=\"3208e81\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-path-to-node=\"11\"><span data-path-to-node=\"11,0\"><b data-path-to-node=\"11,0\" data-index-in-node=\"0\">3.1 Inclusion and Exclusion Criteria.<\/b> <\/span><span data-path-to-node=\"11,2\"><span class=\"citation-294\">A total of 121 male volunteers aged 18 to 79 years who were diagnosed with androgenetic alopecia were selected.<\/span><\/span><span data-path-to-node=\"11,4\">. <\/span><span data-path-to-node=\"11,6\"><span class=\"citation-293\">Exclusion criteria for the purpose of the study represented the presence of psychiatric conditions in the volunteer, the presence of precancerous cutaneous and systemic malignant conditions or severe systemic conditions such as diabetes or cirrhosis, and finally, being under treatment for Androgenetic Alopecia with topical or systemic pharmacological formulations, such as finasteride and minoxidil<\/span><\/span><span data-path-to-node=\"11,8\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><p data-path-to-node=\"12\"><b data-path-to-node=\"12\" data-index-in-node=\"0\">3.2 Characteristics of the products tested<\/b> <b data-path-to-node=\"12\" data-index-in-node=\"41\">Content of Restax nutraceutical:<\/b><\/p><ul data-path-to-node=\"13\"><li><p data-path-to-node=\"13,0,0\"><span data-path-to-node=\"13,0,0,1\"><span class=\"citation-292\">Serenoa repens extract 320 mg: Containing free fatty acids with chain between C12 and C16 and Sitosterol beta as active ingredients, both reduce 5-alpha-reductase activity by binding to the enzyme and inactivating it<\/span><\/span><span data-path-to-node=\"13,0,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"13,1,0\"><span data-path-to-node=\"13,1,0,1\"><span class=\"citation-291\">Beta-sitosterol is also chemically very similar to cholesterol and can therefore compete with it to bind to P450scc, which catalyzes its oxidation to pregnenolone, the precursor of testosterone, potentially slowing the conversion of Testosterone to DHT through this secondary mechanism as well<\/span><\/span><span data-path-to-node=\"13,1,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"13,2,0\"><span data-path-to-node=\"13,2,0,1\"><span class=\"citation-290\">Astaxanthin 2mg: plant-derived carotenoid, extracted from the green alga Haematococcus pluvialis is known for its high antioxidant and anti-inflammatory power<\/span><\/span><span data-path-to-node=\"13,2,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"13,3,0\"><span data-path-to-node=\"13,3,0,1\"><span class=\"citation-289\">Pinus pinaster dry bark extract 50 mg: Containing oligomeric proanthocyanidins, natural antioxidants<\/span><\/span><span data-path-to-node=\"13,3,0,3\">. <\/span><span data-path-to-node=\"13,3,0,5\"><span class=\"citation-288\">Proanthocyanidins help strengthen the elasticity and functionality of the capillary bed by promoting better blood flow to tissues<\/span><\/span><span data-path-to-node=\"13,3,0,7\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><\/ul><p data-path-to-node=\"14\"><b data-path-to-node=\"14\" data-index-in-node=\"0\">Contents of the nutraceutical Restax Flogo 30cps:<\/b><\/p><ul data-path-to-node=\"15\"><li><p data-path-to-node=\"15,0,0\"><span data-path-to-node=\"15,0,0,1\"><span class=\"citation-287\">Epilobium 350mg, Phytosterols 200mg, Proanthocyanidins 27 mg, Astaxanthin 1.3mg<\/span><\/span><span data-path-to-node=\"15,0,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"15,1,0\"><span data-path-to-node=\"15,1,0,1\"><span class=\"citation-286\">The difference from Restax is the higher content in \u03b2-sitosterol titer (140mg per cps)<\/span><\/span><span data-path-to-node=\"15,1,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"15,2,0\"><span data-path-to-node=\"15,2,0,1\"><span class=\"citation-285\">Epilobium extract exerts specific anti-inflammatory action by reducing COX-2 via ellagitannins<\/span><\/span><span data-path-to-node=\"15,2,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><\/ul><p data-path-to-node=\"16\"><span data-path-to-node=\"16,0\"><b data-path-to-node=\"16,0\" data-index-in-node=\"0\">Contents of Trivis Men&#8217;s Lotion 100ml:<\/b> <\/span><span data-path-to-node=\"16,2\"><span class=\"citation-284\">Contains Dimethyl Sulfone, D-Xylose, Melatonin, Sphinganine, Pumpkin Seed Extract, 18 \u03b2-glycyrrhetinic Acid, Caffeine and Sorbitol<\/span><\/span><span data-path-to-node=\"16,4\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><ul data-path-to-node=\"17\"><li><p data-path-to-node=\"17,0,0\"><span data-path-to-node=\"17,0,0,1\"><span class=\"citation-283\">Dimethyl Sulfone: enhances the release of active ingredients.<\/span><\/span><span data-path-to-node=\"17,0,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,1,0\"><span data-path-to-node=\"17,1,0,1\"><span class=\"citation-282\">D-Xylose: humectant and heat-protective agent.<\/span><\/span><span data-path-to-node=\"17,1,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,2,0\"><span data-path-to-node=\"17,2,0,1\"><span class=\"citation-281\">Melatonin: reduces apoptosis and stimulates growth via estrogen receptors<\/span><\/span><span data-path-to-node=\"17,2,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,3,0\"><span data-path-to-node=\"17,3,0,1\"><span class=\"citation-280\">Sphinganine: promotes Anagen phase and rebalances the hair cycle by inhibiting 5 alpha reductase<\/span><\/span><span data-path-to-node=\"17,3,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,4,0\"><span data-path-to-node=\"17,4,0,1\"><span class=\"citation-279\">Pumpkin Seed Extract: anti-androgenic and sebum-regulating action.<\/span><\/span><span data-path-to-node=\"17,4,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,5,0\"><span data-path-to-node=\"17,5,0,1\"><span class=\"citation-278\">18 \u03b2-glycyrrhetinic acid: natural steroid with potent anti-inflammatory effect<\/span><\/span><span data-path-to-node=\"17,5,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p data-path-to-node=\"17,6,0\"><span data-path-to-node=\"17,6,0,1\"><span class=\"citation-277\">Caffeine: reduces the effects of DHT locally.<\/span><\/span><span data-path-to-node=\"17,6,0,3\">.<\/span><\/p><div class=\"source-inline-chip-container ng-star-inserted\"> <\/div><\/li><li><p id=\"p-rc_eec4d48c11f18905-124\" data-path-to-node=\"17,7,0\"><span data-path-to-node=\"17,7,0,1\"><span class=\"citation-276\">Sorbitol: hair cell nutrient with moisturizing action.<\/span><\/span><span data-path-to-node=\"17,7,0,3\">.<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b13593 elementor-widget elementor-widget-heading\" data-id=\"4b13593\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">4. Results\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-85a5944 elementor-widget elementor-widget-text-editor\" data-id=\"85a5944\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-path-to-node=\"18,2\"><span class=\"citation-275\">The study involved 121 men (mean age 38.33 years)<\/span><\/span><span data-path-to-node=\"18,4\">.  <\/span><span data-path-to-node=\"18,6\"><span class=\"citation-274\">At the start of the study, 115 patients had a positive pull test, 112 trichodynia, 115 itching and 119 yellow dots<\/span><\/span><span data-path-to-node=\"18,8\">.  <\/span><span data-path-to-node=\"18,10\"><span class=\"citation-273\">After 6 months of treatment, patients with positive pull-test decreased to 35, those with trichodynia to 17, with itching to 22 and with yellow dots to 25<\/span><\/span><span data-path-to-node=\"18,12\">.  <\/span><span data-path-to-node=\"18,14\"><span class=\"citation-272\">Average overall physician rating increased from 2.802 to 3.512 (+25.34%)<\/span><\/span><span data-path-to-node=\"18,16\">.  <\/span><span data-path-to-node=\"18,18\"><span class=\"citation-271\">The mean value of the Norwood-Hamilton scale improved from 3.479 to 1.933 (-44.44%)<\/span><\/span><span data-path-to-node=\"18,20\">.  <\/span><span data-path-to-node=\"18,22\"><span class=\"citation-270\">No patients complained of any side effects<\/span><\/span><span data-path-to-node=\"18,24\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f733e2b elementor-widget elementor-widget-image\" data-id=\"f733e2b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"791\" height=\"509\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2026\/02\/triv.png\" class=\"attachment-large size-large wp-image-23673\" alt=\"\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2026\/02\/triv.png 791w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2026\/02\/triv-300x193.png 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2026\/02\/triv-768x494.png 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2026\/02\/triv-600x386.png 600w\" sizes=\"(max-width: 791px) 100vw, 791px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cea91f elementor-widget elementor-widget-heading\" data-id=\"4cea91f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">5. Conclusions<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-318fb52 elementor-widget elementor-widget-text-editor\" data-id=\"318fb52\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-path-to-node=\"19,2\"><span class=\"citation-269\">Joint treatment with Restax Flogo and Trivis AGA Men&#8217;s Lotion (first 3 months), followed by Restax 30+30 and lotion (next 3 months), has been shown to be effective in reducing itching, trichodynia, and perifollicular inflammation, as well as strengthening hair by reducing hair loss<\/span><\/span><span data-path-to-node=\"19,4\">. <\/span><span data-path-to-node=\"19,6\"><span class=\"citation-268\">Patients were satisfied with the results obtained .<\/span><\/span><span data-path-to-node=\"19,8\">.<\/span><\/p><p> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-07f6c9c elementor-widget elementor-widget-heading\" data-id=\"07f6c9c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Share the article:<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d61e39 elementor-share-buttons--view-icon-text elementor-share-buttons--skin-gradient elementor-share-buttons--shape-square elementor-grid-0 elementor-share-buttons--color-official elementor-widget elementor-widget-share-buttons\" data-id=\"1d61e39\" data-element_type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\">\n\t\t\t\t\t\t<div\n\t\t\t\t\t\t\tclass=\"elementor-share-btn 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elementor-col-100\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-name\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tName\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"text\" name=\"form_fields[name]\" id=\"form-field-name\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Name\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-email\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tEmail\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"email\" name=\"form_fields[email]\" id=\"form-field-email\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Email\" required=\"required\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-group elementor-column elementor-field-type-submit elementor-col-100 e-form__buttons\">\n\t\t\t\t\t<button class=\"elementor-button elementor-size-sm elementor-animation-grow\" type=\"submit\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-email1\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Sign up<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/form>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdd7102 elementor-widget elementor-widget-heading\" data-id=\"bdd7102\" data-element_type=\"widget\" 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e-con e-child\" data-id=\"afbba4d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:132,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fffb193 elementor-position-left elementor-position-left elementor-vertical-align-top elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"fffb193\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/restax-flogo-30cps\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"838\" height=\"838\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11.webp\" class=\"attachment-full size-full wp-image-4756\" alt=\"\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11.webp 838w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11-300x300.webp 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11-150x150.webp 150w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11-768x768.webp 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11-600x600.webp 600w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2022\/05\/flogo-11-100x100.webp 100w\" sizes=\"(max-width: 838px) 100vw, 838px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h5 class=\"elementor-image-box-title\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/restax-flogo-30cps\/\">Restax Flogo 30CPS<\/a><\/h5><p class=\"elementor-image-box-description\">Restax Flogo 30cps indicated for Male Androgenetic Alopecia Androgenetica with strong inflammatory component<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45d681c elementor-position-left elementor-position-left elementor-vertical-align-top elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"45d681c\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/restax-30cps-30-softgels\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11.webp\" class=\"attachment-full size-full wp-image-11843\" alt=\"\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11.webp 1080w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-300x300.webp 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-1024x1024.webp 1024w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-150x150.webp 150w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-768x768.webp 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-600x600.webp 600w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/restax-11-100x100.webp 100w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h5 class=\"elementor-image-box-title\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/restax-30cps-30-softgels\/\">Restax 30CPS + 30 Softgels<\/a><\/h5><p class=\"elementor-image-box-description\">Restax recommended for normal hair trophism, targeted natural adjuvant for male androgenetic alopecia. Pack of 30 pearls+30 capsules. Serenoa Repens, Astaxanthin and Proanthocyanidins.  <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ca9226 elementor-position-left elementor-position-left elementor-vertical-align-top elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"1ca9226\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/trivis-aga-mens-lotion-100ml\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"612\" height=\"408\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2023\/02\/AGA_UOMO_32-removebg-preview.webp\" class=\"attachment-full size-full wp-image-6985\" alt=\"\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2023\/02\/AGA_UOMO_32-removebg-preview.webp 612w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2023\/02\/AGA_UOMO_32-removebg-preview-300x200.webp 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2023\/02\/AGA_UOMO_32-removebg-preview-600x400.webp 600w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h5 class=\"elementor-image-box-title\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/trivis-aga-mens-lotion-100ml\/\">TriVis AGA Men's Lotion 100ml<\/a><\/h5><p class=\"elementor-image-box-description\">TRIVIS MAN'S LOTION is a topical hair lotion formulated for the purpose of nourishing hair bulbs, reducing inflammation and stimulating hair regrowth in patients with male androgenetic alopecia, thus performing a triple synergistic action.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Clinical trial of Restax and Trivis: efficacy of combined treatment for male alopecia. Significant improvements on hair density and diameter. <\/p>\n","protected":false},"author":1,"featured_media":18697,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,254,253],"tags":[],"class_list":["post-23843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-medica","category-blog-medica-articoli-scientifici","category-blog-medica-casi-clinici"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Multicenter randomized clinical trial of a nutraceutical and a lotion in male patients with androgenetic alopecia<\/title>\n<meta name=\"description\" content=\"Clinical trial of Restax and Trivis: efficacy of combined treatment for male alopecia. 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