{"id":19394,"date":"2024-10-24T11:07:30","date_gmt":"2024-10-24T09:07:30","guid":{"rendered":"https:\/\/wikenfarma.com\/the-importance-of-hesperidin-and-diosmin-for-circulatory-health\/"},"modified":"2025-03-25T09:33:19","modified_gmt":"2025-03-25T08:33:19","slug":"the-importance-of-hesperidin-and-diosmin-for-circulatory-health","status":"publish","type":"post","link":"https:\/\/wikenfarma.com\/en\/the-importance-of-hesperidin-and-diosmin-for-circulatory-health\/","title":{"rendered":"THE IMPORTANCE OF HESPERIDIN AND DIOSMIN FOR CIRCULATORY HEALTH"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"19394\" class=\"elementor elementor-19394 elementor-13824\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-25abc02 e-flex e-con-boxed e-con e-parent\" data-id=\"25abc02\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-63d084f e-con-full e-flex e-con e-child\" data-id=\"63d084f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bbf7f7f elementor-widget elementor-widget-heading\" data-id=\"bbf7f7f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Scientific articles<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91acfc9 elementor-widget elementor-widget-heading\" data-id=\"91acfc9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THE IMPORTANCE OF HESPERIDIN AND DIOSMIN FOR CIRCULATORY HEALTH<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39a9ea2 elementor-widget elementor-widget-heading\" data-id=\"39a9ea2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><i>Treatments for venous insufficiency and hemorrhoidal disease<\/i><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8565c6c elementor-widget elementor-widget-image\" data-id=\"8565c6c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/fleboken-sintomatologia-da-stasi-venosa-crisi-emorroidaria\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-768x512.jpg\" class=\"attachment-medium_large size-medium_large wp-image-13828\" alt=\"esperidina diosmina\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-768x512.jpg 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-300x200.jpg 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-1024x683.jpg 1024w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-1536x1024.jpg 1536w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-2048x1366.jpg 2048w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/10\/young-woman-sitting-on-sofa-suffering-from-leg-pai-2024-10-17-05-02-32-utc-600x400.jpg 600w\" sizes=\"(max-width: 768px) 100vw, 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headings were found on this page.&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t<h4 class=\"elementor-toc__header-title\">\n\t\t\t\tIndex\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__c532805\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__c532805\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t<div id=\"elementor-toc__c532805\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-081b490 elementor-widget elementor-widget-text-editor\" data-id=\"081b490\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.humanitas.it\/enciclopedia\/integratori-alimentari\/esperidina\/\">Hesperidin<\/a> and <a href=\"https:\/\/www.humanitas.it\/enciclopedia\/integratori-alimentari\/diosmina\/\">diosmin<\/a> are two plant-derived <em>flavonoids<\/em> with very important qualities and benefits from the point of view of phytotherapy. Specifically, there are several articles in the literature attesting to the <strong>anti-inflammatory, anti-edemigenous and anti-aggregative<\/strong> abilities of hesperidin and diosmin, especially when they are <i><b><u>combined<\/u> <\/b><\/i>with each other.   [1,2]<\/p><p>This combined combination is already present and widely used for the treatment of hemorrhoidal diseases, precisely because of the anti-inflammatory capabilities of these active ingredients, in fact, there can be a <strong>significant <\/strong>reduction in pain and bleeding associated with this condition.[3][4]<\/p><p>However, the <b>combination of <\/b> <i>hesperidin <\/i>and <i>diosmin<\/i> is not only useful in cases of hemorrhoids, but both active ingredients have significant and important pharmacological activity.<\/p><h3><strong>When to use Esperidin and Diosmin in formulations?<\/strong><\/h3><p><em>Hesperidin<\/em> is obtained from a wide variety of <strong>citrus<\/strong> fruits, while <em>diosmin<\/em> is produced from a wide variety of <strong>plants<\/strong>, but is commonly extracted from the mesocarp of fruits in the genus <strong>Citrus<\/strong>, as is hesperidin.<\/p><p>Both of the molecules mentioned are <a href=\"https:\/\/www.google.com\/search?q=polifenoni&amp;oq=polifenoni&amp;gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIMCAEQABgKGLEDGIAEMgkIAhAAGAoYgAQyCQgDEAAYChiABDIJCAQQABgKGIAEMgkIBRAAGAoYgAQyCQgGEAAYChiABDIJCAcQABgKGIAEMgkICBAAGAoYgAQyCQgJEAAYChiABNIBCDIxNTBqMGo0qAIAsAIA&amp;sourceid=chrome&amp;ie=UTF-8\" target=\"_blank\" rel=\"noopener\">polyphenols<\/a>, diosmin being a flavone-glycoside while hesperidin is a flavanone-glycoside, specifically this makes them <i>water-soluble <\/i>though endowed with a particularly sour taste to the palate.[4]<\/p><p>Being <i><u>polyphenols<\/u><\/i>, both molecules are therefore capable of exerting important <b>antioxidant <\/b>and <b>anti-inflammatory<\/b> activity, as well as having &#8220;vitamin-like&#8221; activity that reduces capillary permeability: in fact, for a long time these and other polyphenols were known as <a href=\"https:\/\/www.pazienti.it\/contenuti\/valori-nutrizionali\/vitamina-p\" target=\"_blank\" rel=\"noopener\">&#8220;vitamin P.&#8221;<\/a>[5]<\/p><p>This reduction in capillary permeability is precisely one of the effects underlying the improvement in skin microcirculation experienced by those taking diosmin and hesperidin combination products.<\/p><h3><strong>Treatment of venous insufficiency<\/strong><\/h3><p>By virtue of this property, and anti-aggregant properties, diosmin and hesperidin also exert <strong>an action to counter venous stasis.<\/strong>[1,2] Diosmin is capable of binding to prothrombin, inhibiting it, and this binding is stronger if diosmin has been metabolized with production of diosmin sulfate.<\/p><p>Lastly, diosmin and hesperidin exhibit some <b>antihypertensive activity<\/b>, acting both on the venous smooth muscle to induce its relaxation and reducing the amount of free superoxide (<sup>O2-<\/sup>) anions in the blood due to their antioxidant activity.<\/p><p>The latter chemical species is of particular interest because it has an action on nitrogen oxides that are naturally present in the blood and act as vasodilators. The superoxide ion reacts with these chemical species to form peroxynitrite, an oxidizing chemical species that damages the cells of the venous endothelium. In addition, <sub>O2-<\/sub> ion<sup> is <\/sup>also a strong oxidant that, if not inactivated, damages membrane lipids, proteins, and DNA.   [6]<\/p><p>Because of the characteristics already discussed, Diosmin and hesperidin have been included, together with other active ingredients with <a href=\"https:\/\/it.wikipedia.org\/wiki\/Melilotus_officinalis\" target=\"_blank\" rel=\"noopener\">antiplatelet action, the coumarins of melilotus<\/a>, and vasodilator action, the escin of <a href=\"https:\/\/www.cure-naturali.it\/enciclopedia-naturale\/rimedi-naturali\/erboristeria\/ippocastano.html\" target=\"_blank\" rel=\"noopener\">horse chestnut<\/a> extract, in the formulation of <a href=\"https:\/\/wikenfarma.com\/en\/fleboken\/\">Fleboken 36cps<\/a>, a product created by <b>Wikenfarma <\/b>research in order to give a strong answer to the problem of venous insufficiency and hemorrhoidal disease.<\/p><p>In detail, it is a <i> <b><u>specific<\/u> <\/b> nutraceutical for<\/i>the treatment of <b>venous stasis<\/b> with a powerful anti-oedemigenic effect, reducing fluid accumulation and safeguarding capillary health. In contrast to alternatives on the market, which often have very heavy side effects, <b><i>Fleboken <u>does not<\/u> present any side effects<\/i><\/b> related to circulation, proving to be the <i> <u style=\"font-weight: bold;\">most viable and safe<\/u> formulation<\/i>. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8adeb85 elementor-widget elementor-widget-heading\" data-id=\"8adeb85\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">For more information...<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b15538 elementor-widget elementor-widget-button\" data-id=\"5b15538\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div 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icon-calendar-page-empty\"><\/i>\n\t\t\t\t\t\t\t\t24 Jun 2025\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">THEY TALK ABOUT TRIVIS UV ON \u201cTHE SKIN\u201d<\/span>\n\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t<\/li>\n\t\t\t\t\t<li class=\"elementor-icon-list-item   \">\n\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/on-the-benefits-of-hyaluronic-acid-on-scalp-and-follicles\/\" >\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/06\/Foto-per-blog-WKF-50-1024x1024.png\" class=\"attachment-large size-large wp-post-image\" alt=\"ACIDO IALURONICO CAPELLI\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/06\/Foto-per-blog-WKF-50-1024x1024.png 1024w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2025\/06\/Foto-per-blog-WKF-50-300x300.png 300w, 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AND FOLLICLES<\/span>\n\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de56588 elementor-widget elementor-widget-heading\" data-id=\"de56588\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Products in this article:<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0142a3b e-con-full e-flex e-con e-child\" data-id=\"0142a3b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:132,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-efdc406 elementor-position-left elementor-position-left elementor-vertical-align-top elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"efdc406\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/wikenfarma.com\/en\/fleboken\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"1270\" height=\"1080\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box.webp\" class=\"attachment-full size-full wp-image-11670\" alt=\"fleboken\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box.webp 1270w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box-300x255.webp 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box-1024x871.webp 1024w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box-768x653.webp 768w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2024\/07\/fleboken-box-600x510.webp 600w\" sizes=\"(max-width: 1270px) 100vw, 1270px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h5 class=\"elementor-image-box-title\"><a href=\"https:\/\/wikenfarma.com\/en\/fleboken\/\">Fleboken 30CPS<\/a><\/h5><p class=\"elementor-image-box-description\">Fleboken is an adjuvant supplement for cellulite and venous stasis high in diosmin, hesperidin, melilot, horse chestnut and rutin<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d32a354 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d32a354\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b824d37\" data-id=\"b824d37\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c2e07c elementor-widget elementor-widget-heading\" data-id=\"8c2e07c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\"><p style=\"font-size: 20px; text-align: justify; white-space-collapse: collapse;\"><span style=\"font-weight: bolder;\">Bibliography<\/span><span style=\"color: inherit; font-family: inherit; font-size: 1.75rem; white-space-collapse: preserve;\"><\/span><\/p><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9a5371 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b9a5371\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>[1] Huwait E, Mobashir M. Potential and Therapeutic Roles of Diosmin in Human Diseases. Biomedicines. 2022 May;10(5):1076.  <\/em><\/p><p><em>[2] Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sci. 2015 Mar;124:64-74.  <\/em><\/p><p><em>[3] Romano L, Nervini A, Stia S, Schietroma M, Giuliani A. A combination of diosmin, hesperidin, and ruscogenin. Formosan Journal of Surgery. 2022;55(4):129-33.  <\/em><\/p><p><em>[4] Singh S, Strydom M, Balmith M, Megaw C, Nell M. The role of flavonoids in the pharmacological treatment of haemorrhoids. South African General Practitioner. 2024 Mar;5(1):36-44.  <\/em><\/p><p><em>[5] Garg A, Garg S, Zaneveld LJD, Singla AK. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytotherapy Research. 2001 Dec;15(8):655-69.   <\/em><\/p><p><em>[6] Cuzzocrea S, Mazzon E, Dugo L, Di Paola R, Caputi AP, Salvemini D. Superoxide: a key player in hypertension. The FASEB Journal. 2004 Jan;18(1):94-101.  <\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Discover the vital role of Hesperidin and Diosmin in circulatory health!<\/p>\n","protected":false},"author":1,"featured_media":18726,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[265,270,274],"tags":[],"class_list":["post-19394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en","category-medical-blog","category-medical-blog-scientific-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The importance of Hesperidin and Diosmin in the circulatory system<\/title>\n<meta name=\"description\" content=\"Discover the vital role of 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