{"id":19181,"date":"2022-12-29T08:58:21","date_gmt":"2022-12-29T07:58:21","guid":{"rendered":"https:\/\/wikenfarma.com\/vitiwiken-creama-new-approach-to-vitiligine\/"},"modified":"2025-03-25T09:33:49","modified_gmt":"2025-03-25T08:33:49","slug":"vitiwiken-creama-new-approach-to-vitiligine","status":"publish","type":"post","link":"https:\/\/wikenfarma.com\/en\/vitiwiken-creama-new-approach-to-vitiligine\/","title":{"rendered":"VITIWIKEN CREAM:<br><em>A new approach to VITILIGINE.<\/em>"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"19181\" class=\"elementor elementor-19181 elementor-6403\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d80c93 e-flex e-con-boxed e-con e-parent\" data-id=\"5d80c93\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0864009 e-con-full e-flex e-con e-child\" data-id=\"0864009\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bee66fd elementor-widget elementor-widget-heading\" data-id=\"bee66fd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Scientific articles<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bb26c5 elementor-widget elementor-widget-heading\" data-id=\"9bb26c5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">VITIWIKEN CREAM: <br> a new approach to Vitiligo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0aab885 elementor-widget elementor-widget-heading\" data-id=\"0aab885\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><i>Maria Efenesia Baffa, Roberto Maglie, Francesca Montefusco, Stefano Senatore, Emiliano Antiga Department of Health Sciences - Section of Dermatology, University of Florence.<\/i><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c40ff47 elementor-widget elementor-widget-image\" data-id=\"c40ff47\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/prodotto\/vitiwiken-crema\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-32-768x512.webp\" class=\"attachment-medium_large size-medium_large wp-image-1389\" alt=\"\" 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class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-24195a2 elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/author\/wikenfarma\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-user-circle\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\twikenfarma\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-e32289b elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/wikenfarma.com\/en\/2022\/12\/29\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>December 29, 2022<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1b0859 elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"b1b0859\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;,&quot;h3&quot;,&quot;h4&quot;,&quot;h6&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;numbers&quot;,&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t<h4 class=\"elementor-toc__header-title\">\n\t\t\t\tIndex\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__b1b0859\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__b1b0859\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t<div id=\"elementor-toc__b1b0859\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b7ec03 elementor-widget elementor-widget-text-editor\" data-id=\"6b7ec03\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8221; <b>Vitiligo<\/b> is a chronic pigmentation disorder that is characterized by a reduction in the activity and number of melanocytes in the affected skin. The condition affects between <b>0.5%<\/b> and <b>2% of the world&#8217;s population<\/b>, with no obvious differences in incidence between males and females. Onset can occur in all age groups, but it is most common in the 10- to 30-year-old age group. Vitiligo is currently classified into <i>segmental<\/i><b>(SV<\/b>) and <i>nonsegmental<\/i><b>(NSV<\/b>). of which there are several variants: <i>mucosal, focal, acrofacial, generalized, universal<\/i>, and some rarer variants.    <\/p><p>The clinic is characterized by the appearance of <b>hypopigmented<\/b> or <b>achromic<\/b>, non-desquamating, usually asymptomatic <b>macules<\/b> that can affect any part of the body, mostly symmetrically. The pathogenesis of vitiligo remains largely <i><u>largely unknown<\/u><\/i>, hence the difficulty in finding targeted and effective therapies, especially in the long term. <\/p><p>Numerous studies have shown that oxidative stress plays a primary role in the development of vitiligo. In this regard, melanocytes isolated from vitiligo patients have been shown to be more susceptible to cell damage induced by <i><b>oxidative stress<\/b><\/i>. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75b11e7 elementor-widget elementor-widget-heading\" data-id=\"75b11e7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Read the full article!<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e711677 elementor-widget elementor-widget-button\" data-id=\"e711677\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/drive.google.com\/file\/d\/11Y4l-kl305zRLzzk9Pr0bt2m0okYRP7-\/view?usp=sharing\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click here<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bad871e elementor-widget elementor-widget-text-editor\" data-id=\"bad871e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>An imbalance of the oxidoreductive system has been observed with an &#8216;<b><i>elevation of oxidative stress markers<\/i><\/b> (superoxide dismutase, malondialdehyde, ROS) and antioxidant activity. Therefore, the hypothesis has been advanced that the melanocyte, as a result of oxidative stress-induced cellular damage, which causes cell death by melanocyte apoptosis, may unmask or release proteins that subsequently serve as antigens and activate the cell-mediated immune response against other melanocytes. In such observations lies the rationale for the use of <u>topical<\/u> and\/or <u>systemic<\/u> <u>antioxidants<\/u> in the treatment of vitiligo, the use of which several open trials support.  <\/p><p>Among the various substances with antioxidant power, <u style=\"font-weight: bold;\">PIPER NIGRUM<\/u>, a plant belonging to the Piperaceae family and cultivated mainly in <i>tropical regions<\/i> (Indonesia, Brazil and India), is particularly interesting in vitiligo.<\/p><p>This particular species owes its antioxidant properties, along with its antihistamine, antimicrobial properties, to its main alkaloid, piperine. In addition, both in vitro and in vivo studies show that <i>P. nigrum<\/i> also has melanocyte <b style=\"font-style: italic;\">proliferation-stimulating effects<\/b>. <\/p><p>The <b><i>repigmentation<\/i><\/b> generally observed following the topical use of P. nigrum preparations follows a perifollicular pattern in the early stages, this finding is consistent with the scientific literature, which asserts precisely that repigmentation is possible in areas where there are pigmented hairs, an element suggestive of the presence of a melanin reservoir.<\/p><p>Another molecule of wide interest for its antioxidant power is the <b><u>resveratrol<\/u><\/b>, a component extracted from the roots of the plant Veratrum grandiflorum. It is a natural polyphenol produced by the plant as a result of UV damage or as a defense mechanism against pathogenic microorganisms. [&#8230;]&#8221;  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-861f3cb elementor-widget elementor-widget-heading\" data-id=\"861f3cb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Read the full article!<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68c1450 elementor-widget elementor-widget-button\" data-id=\"68c1450\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/drive.google.com\/file\/d\/11Y4l-kl305zRLzzk9Pr0bt2m0okYRP7-\/view?usp=sharing\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click here<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ddc0ce elementor-widget elementor-widget-heading\" data-id=\"9ddc0ce\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Share the article on your socials!<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92a16ec elementor-share-buttons--view-icon-text elementor-share-buttons--skin-gradient elementor-share-buttons--shape-square elementor-grid-0 elementor-share-buttons--color-official elementor-widget elementor-widget-share-buttons\" data-id=\"92a16ec\" data-element_type=\"widget\" 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data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Products in this article:<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-23b27ac e-con-full e-flex e-con e-child\" data-id=\"23b27ac\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:132,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b8bcda elementor-position-left elementor-position-left elementor-vertical-align-top elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"4b8bcda\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/vitiwiken-cream-50ml\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-11-removebg-preview.png\" class=\"attachment-full size-full wp-image-15847\" alt=\"\" srcset=\"https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-11-removebg-preview.png 500w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-11-removebg-preview-300x300.png 300w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-11-removebg-preview-150x150.png 150w, https:\/\/wikenfarma.com\/wp-content\/uploads\/2021\/07\/Vitiwiken-crema-11-removebg-preview-100x100.png 100w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h5 class=\"elementor-image-box-title\"><a href=\"https:\/\/wikenfarma.com\/en\/prodotto\/vitiwiken-cream-50ml\/\">VITIwiken Cream 50ml<\/a><\/h5><p class=\"elementor-image-box-description\">VITIwiken Crema is a cream with high antioxidant power that contributes topically to promote repigmentation of areas affected by vitiligo<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>VITIWIKEN CREAM: A new approach to VITILIGINE studied by Wikenfarma research and produced in Italy. Publication in the Journal of Plastic and Pathology Dermatology (JPD). <\/p>\n","protected":false},"author":1,"featured_media":18222,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[265,270,274],"tags":[],"class_list":["post-19181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en","category-medical-blog","category-medical-blog-scientific-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>JPD ARTICLE - New approach to vitiligo - WikenBlog<\/title>\n<meta name=\"description\" content=\"VITIWIKEN CREAM: A new approach to VITILIGINE designed by Wikenfarma research and produced in Italy\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wikenfarma.com\/en\/vitiwiken-creama-new-approach-to-vitiligine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JPD ARTICLE - 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