Phytoestrogens are substances contained in plants that, by composition and effects on the human body, are termed ”estrogen-like”: they act, in fact, like mild estrogens.

There are many plants that contain phytoestrogens: notable among them is Kudzu, a climbing plant of Asian origin (widespread mainly in China and Japan) rich in isoflavones, such as genistein, daidzein, and puerarin. The part of the plant used for its high phytoestrogen content is the root part.

Extracts with Puerarin concentrations of up to 40% can be obtained from the tuberized root, making Kudzu one of the most important alternatives to soy for isoflavone supply.

Puerarin, considered the plant’s active ingredient, makes Kudzu supplementation in the diet succeed in reducing the occurrence of hot flashes, facilitates bone remineralization, aids the cardiovascular system, and calms nervous hunger. In fact, Puerarin acts on neurotransmitters as an adaptogen, stimulating serotonin and dopamine production by balancing mood and facilitating nighttime sleep.

The renewed hormonal balance achieved through the introduction of phytoestrogens into the diet allows for hair reinvigoration, as phytoestrogens have the ability to activate the Anagen (growth) phase of the hair.

Hops are also a widely used plant for the phytoestrogens they contain. Among them is hopein, isolated by researchers at the University of Ghent (Belgium) in collaboration with King’s College (UK), currently known to be the most potent phytoestrogen currently known, about 100 times more active than genistein and daidzein.

LUPPLE and KUDZU in synergy physiologically increase ESTRONE synthesis, stimulate stem cells and thus the ANAGEN phase of the hair.

Restax Donna Plus 30cps is the targeted answer for female alopecia in cases of Female Defluvium from estrogen deficiency, Postmenopausal Defluvium, Anovulation Defluvium.

The clinical picture frequently presenting is as follows:

-Thinning hair

-Thinning hair

Rarely it is also associated:

• Excessive level of androgen hormones with occurrence of hirsutism and acne
• polycystic ovary
• hyperinsulinisation

AGNOCASTO is a natural source of PROGESTERONE which is able to inhibit by naturally regulating 5-alpha-reductase by competition with TESTOSTERONE.

AGNOCASTO through P450 AROMATASIS physiologically potentiates the metabolic pathway ofESTRONE (estrogen hormone): it increases the activity ofADENYLCYCLASE, lengthens the ANAGEN phase, and activates STAMINAL cells.

AGNOCASTO physiologically reduces the formation of DHT which reduces the activity ofADENYL CYCLASE.

In turn,ADENYL CYCLASIS induces TELOGEN.

AGNOCASTO through P450 AROMATASIS physiologically potentiates the metabolic pathway ofESTRONE (estrogen hormone): it increases the activity ofADENYLCYCLASE, lengthens the ANAGEN phase, and activates STAMINAL cells.

In WOMEN the P450 AROMATASIS enzyme is markedly more highly expressed than in humans.

NICOTINAMIDE improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha-reductase activity.

RESVERATROL powerful antioxidant and anti-inflammatory, physiologically blocks follicle loss and protects it from HYALINOSIS (atrophy/scarring).

NICOTINAMIDE improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha-reductase activity.

BIOTIN must be taken in supplements or through the diet since the body is unable to synthesize it. It is a very important coenzyme for fat and carbohydrate metabolism: its deficiency causes alopecia, thinning and loss of natural hair color.

PIPER NIGRUM activates intestinal transport carriers and enhances the absorption of active ingredients, making them more BIOAVAILABLE.

In addition, Piper Nigrum has demonstrated physiological 5-alpha reductase inhibitory activity.

Posology: 1 capsule during dinner for at least 6 months

Restax Donna Plus® supplement, thanks to its nutrients, has been shown to be effective in promoting the reduction of hair loss and improving hair diameter, in patients with telogen effluvium and mild-to-moderate androgenetic alopecia.

Chasteberry (Vitex agnus-castus) is a herb known for more than 2,000 years for its progestin activities. Recent studies in the literature have further demonstrated its usefulness related to gynecological disorders, such as menstrual cycle alterations resulting from corpus luteum insufficiency, including premenstrual syndrome and dysmenorrhea, in polycystic ovary syndrome, and for some menopausal conditions. In addition, it has been found to inhibit, by naturally regulating 5-alpha reductase by competition, testosterone.

A number of potent polyphenols, including Resveratrol, have been shown to activate the transition from the telogen to the anagen phase of the follicular cycle through the activation of TERT (the telomerase reverse transcriptase potential). Overexpression of TERT in the skin in fact activates resting hair follicle bulge stem cells, triggering a new follicle growth phase, promoting hair regrowth. The ability of polyphenols to also regulate the gene expression of cytokines such as IGF-1and KGF (which activate the β-catenin pathway), and TGF- β 1, which play an important role in maintaining the hair follicle stem cell niche, has also been demonstrated, and are therefore believed to play a role in promoting hair growth.

Resveratrol also significantly reduces oxygen peroxide-induced oxidative stress generated in the hair follicle and hair matrix cells, resulting in a significant increase in hair density.

Ethanolic extracts of Piper Nigrum have been shown to have 50% 5a-reductase enzyme inhibiting activity and melanogenesis-promoting activity in the follicular bulb, proving to be an excellent cosmetic adjuvant against hair thinning and hair loss.

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble vitamin and an essential cofactor for carboxylase enzymes in multiple metabolic pathways, such as protein synthesis and more specifically, in keratin production. This explains its contribution to healthy hair growth in increasing root strength and accelerating growth rate.

Nicotinamide improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha reductase activity.