AGNOCASTO physiologically reduces the formation of DHT which reduces the activity of ADENYL CYCLASE.

In turn, ADENYL CYCLASIS induces TELOGEN.

AGNOCASTO through P450 AROMATASIS physiologically enhances the metabolic pathway of ESTRONE (estrogen hormone): it increases ADENYLCYCLASE activity, lengthens ANAGEN phase, and activates STAMINAL cells

In WOMEN the enzyme P450 AROMATASIS is markedly more highly expressed than in humans

RESVERATROL powerful antioxidant and anti-inflammatory, physiologically blocks follicle loss and protects it from HYALINOSIS (atrophy/scarring)

NICOTINAMIDE improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha-reductase activity

BIOTIN must be taken in supplements or through the diet since the body is unable to synthesize it. It is a very important coenzyme for fat and carbohydrate metabolism: its deficiency causes alopecia, thinning and loss of natural hair color.

PIPER NIGRUM activates intestinal transport carriers and enhances the absorption of active ingredients, making them more BIOAVAILABLE.

In addition, Piper Nigrum has demonstrated physiological 5-alpha reductase inhibitory activity.

Chasteberry (Vitex agnus-castus) is a herb known for more than 2,000 years for its progestin activities. Recent studies in the literature have further demonstrated its usefulness related to gynecological disorders, such as menstrual cycle alterations resulting from corpus luteum insufficiency, including premenstrual syndrome and dysmenorrhea, in polycystic ovary syndrome, and for some menopausal conditions. In addition, it has been found to inhibit, by naturally regulating 5-alpha reductase by competition, testosterone.

Some potent polyphenols, including the Resveratrol, have been shown to activate the transition from the telogen to the anagen phase of the follicular cycle through the activation of TERT (the telomerase reverse transcriptase potential). Overexpression of TERT in the skin in fact activates resting hair follicle bulge stem cells, triggering a new follicle growth phase, promoting hair regrowth. The ability of polyphenols to also regulate the gene expression of cytokines such as IGF-1and KGF (which activate the β-catenin pathway), and TGF- β 1, which play an important role in maintaining the hair follicle stem cell niche, has also been demonstrated, and are therefore believed to play a role in promoting hair growth.

Resveratrol also significantly reduces oxygen peroxide-induced oxidative stress generated in the hair follicle and hair matrix cells, resulting in a significant increase in hair density.

The ethanolic extracts of Piper Nigrum have been shown to have 50% 5a-reductase enzyme inhibitory activity and melanogenesis-promoting activity in the follicular bulb, proving to be an excellent cosmetic adjuvant against hair thinning and hair loss.

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble vitamin and an essential cofactor for carboxylase enzymes in multiple metabolic pathways, such as protein synthesis and more specifically, in keratin production. This explains its contribution to healthy hair growth in increasing root strength and accelerating growth rate.

Nicotinamide improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha reductase activity.