RESTAX EFFLUVIUM 30 cpr is RECOMMENDED IN CASE OF seasonal, stress-induced hair loss. It physiologically combats trichotillomania.

N-ACETYL CYSTEINE (NAC): YOUR ALLY AGAINST OXIDATIVE STRESS

1. NAC is the precursor of GLUTATIONE but unlike glutathione itself, it is able to cross the blood-brain barrier. At the CNS level it is then converted to glutathione which in turn is converted to Cysteine, Glycine and Glutamate. Cysteine dimerizes into Cystine which is transported within astrocytes near the Nucleus Accumbens in exchange with glutamate. The increase in extracellular glutamate results in an inhibition of glutaminergic (excitatory) transmission, resulting in a predominance of GABAergic (inhibitory) transmission.

2. In addition, neuronal Glutathione modulates DOPAMINE release and NMDA receptor activity in the nucleus striatum and limbic system, particularly in the Nucleus Accumbens, systems that play a key role in several disorders. In fact, Acetylcysteine has been successfully tested, in the treatment of schizophrenia, mood disorders (depression, mania), bipolar disorder, obsessive-compulsive disorder, and also in addictions, impulse control disorder, TRICOTILLOMANIA, and dermatillomania.

3. NAC also has a potent antioxidant action as a glutathione precursor, so it is widely used and is being studied as a therapy to reduce the OXIDATIVE STRESSgeneratedby the inflammatory cascade during Sars-Cov2 infection.

5-OH TRIPTOPHAN: Amino acid precursor of SEROTONIN
1. It is converted at the CNS level to Serotonin, a neurotransmitter
implicated in the regulation of mood, sleep and appetite

6. Serotonin also is a precursor of MELATONIN, involved
directly in the hair cycle with antiapoptotic and antioxidant effects and BIOTINcoenzymeimportant for fat and carbohydrate metabolism: its deficiency causes alopecia, thinning and loss of natural hair color. ZINC Essential mineral on which numerous enzymatic activities depend; its deficiency can cause hair changes including TELOGEN EFFLUVIUM.