Restax Donna Plus is recommended in postmenopausal female alopecia.

Restax Donna Plus contains Hops, Kudzu Isoflavones, Chasteberry, Resveratrol, and Piper Nigrum with Biotin and Niacin.Female Alopecia affects up to 40 percent of menopausal women.
One of the most effective ways to counteract it is to improve peripheral estrogen content through the use of phytoestrogens. Phytoestrogens are substances contained in plants that, due to their composition and effects on the human body, are defined as ”estrogen-like”: they act, in fact, as mild estrogens.There are numerous plants that contain phytoestrogens: among them is Kudzu, a climbing plant of Asian origin (widespread mainly in China and Japan) rich in isoflavones, such as genistein, daidzein, and puerarin.

The part of the plant used for its high phytoestrogen content is the root. Extracts with Puerarin concentrations of up to 40 percent can be obtained from the tuberized root,
making Kudzu one of the most important alternatives to soy for isoflavone supply. Puerarin, considered the plant’s active ingredient, makes Kudzu dietary supplementation successful in reducing the occurrence of hot flashes, facilitates bone remineralization, aids the cardiovascular system, and calms nervous hunger.

In fact, Puerarin acts on neurotransmitters as an adaptogen, stimulating serotonin and dopamine production by balancing mood and facilitating nighttime sleep. The renewed hormonal balance achieved through the introduction of phytoestrogens into the diet allows for hair reinvigoration, as phytoestrogens have the ability to activate the Anagen (growth) phase of the hair. Hops is also a widely used plant for the phytoestrogens it contains.

Among them is hopein, isolated by researchers at the University of Ghent (Belgium) in collaboration with King’s College (UK), currently known as the most potent phytoestrogen currently known, about 100 times more active than genistein and daidzein.LUPPLE and KUDZU in synergy physiologically increase ESTRONE synthesis, stimulate stem cells and thus the ANAGEN phase of the hair.Restax Donna Plus 30cps is the targeted answer for female alopecia in cases of Female Defluvium from estrogen deficiency, Post-menopausal Defluvium, Defluvium from anovulation.The clinical picture frequently presenting is as follows:
-Thinning hair
-Thinning hair

Rarely also associated with:
– excessive level of androgen hormones with appearance of hirsutism and acne
– polycystic ovary
– hyperinsulinisation

AGNOCASTO is a natural source of PROGESTERONE which is able to inhibit by naturally regulating 5-alpha-reductase by competition with the TESTOSTERONE.THE AGNOCASTO through the P450 AROMATASIS physiologically potentiates the metabolic pathway of ESTRONE (estrogen hormone): increases the activity of ADENYL CYCLASE., lengthens the ANAGEN and activates the STAMINAL CELLS. AGNOCASTO physiologically reduces the formation of DHT which reduces the activity of ADENYL CYCLASE..In turn. ADENYL CYCLASIS induces the TELOGEN.

In WOMEN the P450 AROMATASIS enzyme is markedly more highly expressed than in humans.The NICOTINAMIDE enhances peripheral vasodilation and follicle perfusion, also increases levels of NADP by reducing the activity of 5-alpha reductase.The RESVERATROL a potent antioxidant and anti-inflammatory, physiologically blocks follicle loss and protects it from HYALINOSIS (atrophy/scarring).

La NICOTINAMIDE improves peripheral vasodilatation and follicle perfusion, also increases levels of NADP by reducing 5-alpha reductase activity.

La BIOTIN must be taken in supplements or through the diet as the body is unable to synthesize it. It is a very important coenzyme for fat and carbohydrate metabolism: its deficiency causes alopecia, thinning and loss of natural hair color.

The PIPER NIGRUM activates intestinal transport carriers and enhances the absorption of active ingredients, making them more BIOAVAILABLE. In addition, Piper Nigrum has demonstrated physiological 5-alpha reductase inhibitory activity.

Nutritional values:
Chasteberry e.s……………200 mg Of which agnuside…1 mg
Hops …………………..200 mg Of which Rutin…….0.8 mg
Kudzu……………………….150 mg Of which Isoflavones….60 mg
Resveratrol……………….44 mg
Piper Nigrum………………..7 mg
Vitamin B3………………..25 mg
Biotin……………………450 mcg

Posology: 1 capsule during dinner for at least 6 months

Restax Donna Plus® supplement, thanks to its nutrients, has been shown to be effective in promoting the reduction of hair loss and improving hair diameter, in patients with telogen effluvium and mild-to-moderate androgenetic alopecia.

Chasteberry (Vitex agnus-castus) is a herb known for more than 2,000 years for its progestin activities.

Recent studies in the literature have further demonstrated its usefulness related to gynecological disorders, such as menstrual cycle alterations resulting from corpus luteum insufficiency, including premenstrual syndrome and dysmenorrhea, in polycystic ovary syndrome, and for some menopausal conditions.

In addition, it has been found to inhibit, by naturally regulating 5-alpha reductase by competition, testosterone.

Some potent polyphenols, including Resveratrol, have been shown to activate the transition from the telogen to the anagen phase of the follicular cycle through activation of TERT (the telomerase reverse transcriptase potential).

Overexpression of TERT in the skin indeed activates the stem cells of the resting hair follicle bulge, triggering a new follicle growth phase, promoting hair regrowth.

The ability of polyphenols to also regulate the gene expression of cytokines such as IGF-1and KGF (which activate the β-catenin pathway), and TGF- β 1, which play an important role in maintaining the hair follicle stem cell niche, has also been demonstrated, and are therefore believed to play a role in promoting hair growth.

Resveratrol also significantly reduces oxygen peroxide-induced oxidative stress generated in the hair follicle and hair matrix cells, resulting in a significant increase in hair density.

Ethanolic extracts of Piper Nigrum have been shown to have 50% 5a-reductase enzyme inhibiting activity and melanogenesis-promoting activity in the follicular bulb, proving to be an excellent cosmetic adjuvant against hair thinning and hair loss.

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble vitamin and an essential cofactor for carboxylase enzymes in multiple metabolic pathways, such as protein synthesis and more specifically, in keratin production. This explains its contribution to healthy hair growth in increasing root strength and accelerating growth rate.

Nicotinamide improves peripheral vasodilatation and follicle perfusion, also increases NADP levels by reducing 5-alpha reductase activity.

Bibliography
BiolPharm Bull. 2007 Dec;30(12):2402-5; “Testosterone 5alpha-reductase inhibitoryactiveconstituents of Piper nigrumleaf”;Hirata N1, Tokunaga M, Naruto S, Iinuma M, Matsuda H.Arnoux M.: “Administration percutanéedesstroïdes” NouvPresMéd 1979; 8: 3797; Cherif-Cheik J.L., De Lignieres B.: “Traitement de la séborrhéeducuirchevelu par la progesterone percutanée “Thérapeutique Sem. deshopitaux de Paris 1974; 50: 489.Fayolle J.: “La progesteronepercutanéans le traitement de l’acne et desétatsséborrheiques de la peau et ducuirchevelu. Etude de 66 cas” Lyon Medical 1975; 233: 1303.Feldmann R.J., Maibach H.I.: “percutaneous penetration of steroids in man” J Invest Dermatol 1969; 52: 89.Franceschini P.: “Prévention de la calvitie. Séborrhée et progestéronepercutanée” Vie Medicale 1975; 1: 1569.Hellman L., Yoshida K., Zumoff B.: “The effect of medrossyprogesterone acetate on the pituitary-adrenal axis” J ClinEndocrinMetab 1976; 42: 912.Manfredi G.: “Considerations on the antiandrogenic activity of progesterone” Med Est 1981; 4: 160.Marliani A.: “The medical therapy of common baldness” Etruria Medica, Florence, 1992.Mauvais-Jarvis P., Baudod N., Bercovici J.P.: “In vivo studies on progesterone metabolism by human skin” J ClinEndocrinMetab 1969; 29: 1580.Mauvais-Jarvis P., Kuttenn F., Baudod N.: “Inhibition of testosterone conversion to dihydrotestosterone in man treated percutaneously by progesterone” J Clin Endocrinol Metabol 1974; 38: 142.Mauvais-JarvisP.,Kuttenn F., Writh F.: “La progesterone administrée per voiepercutanée. Un antiandrogene à actin locale” Annales d’Endocrinologie 1975; 55: 36.Mauvais-Jarvis P.: “Progésterone et progestatifs” Annales d’Endocrinologie 1979; 40: 357.Occella C., Schiazza L., Nemelka O., Alpigiani M.G., Rampini E.: “Progesterone in the topical treatment of noninflammatory acne” Med Est 1985; 2: 63.Prince V.H.: “Testosterone metabolism in the skin” Arch. Derm 1975; 11: 1496.Scheuplein R.J., Blanck I.H., Brauner G.J., MacFarlane D.J.: “Percutaneous absorption of steroids” J Invest Dermatol 1969; 52: 63.Van Der Willigen A.H., Peereboom-Wyna J.D.R., Van Joost Th., Stolz E.: “A preliminary study of the effect of 11 alpha-hydroxyprogesterone on the hair growth in men suffering from androgenic alopecia. “Acta DermVenereol 1987; 67: 82.Voigt W., Hsia S.L.: “Further studies on testosterone 5 alpha reductase of human skin. Structuralfeatures of steroidinhibitors” J BiolChem 1973; 248: 420.Zappalà F., Caruso A., Giardina A., Randazzo S.D.: “Therapeutic activity of progesterone 0.5% solution in some androgen-dependent dermatoses” Med Est 1983; 3: 113.Biol Pharm Bull. 2007 Dec;30(12):2402-5. “Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrumleaf. “Hirata N1, Tokunaga M, Naruto S, Iinuma M, Matsuda H.